Karlin R, Dumont M, Long B
J Gynecol Obstet Biol Reprod (Paris). 1977 Jun;6(4):489-95.
When the blood levels of folates were estimated in 100 women following treatment with oestro-progestagens the following facts emerged : 1) There is no significant difference between the folate levels found in women on oestro-progestagens compared with a control population of the same age. 2) We have not found any evidence of frank folic acid deficiency in women on oestro-progestagens, but there have been slight drops in the levels of folates in women who show other reasons for folic acid deficiency than taking oral contraceptives. These are : troubles in absorption, salmonella, an increase in the need for folic acid in pregnancy, and failure of transport. Furthermore the incidence of lower levels in the control population was exactly the same as in the experimental population.
在对100名接受雌激素 - 孕激素治疗的女性进行叶酸水平评估时，发现了以下情况：1）服用雌激素 - 孕激素的女性的叶酸水平与相同年龄的对照人群相比，没有显著差异。2）我们没有发现服用雌激素 - 孕激素的女性存在明显的叶酸缺乏证据，但在那些因除服用口服避孕药之外的其他原因导致叶酸缺乏的女性中，叶酸水平出现了轻微下降。这些原因包括：吸收障碍、沙门氏菌感染、孕期对叶酸需求增加以及转运障碍。此外，对照人群中叶酸水平较低的发生率与实验人群完全相同。
