Demeurisse G, Hublet C, Paternot J, Colson C, Serniclaes W
Service de Revalidation Neurologique, CHU Brugmann, Brussels, Belgium.
Neuropsychologia. 1997 May;35(5):731-5. doi: 10.1016/s0028-3932(96)00126-1.
The pathophysiology of neuropsychological disorders due to right deep-seated hemispheric lesions remains a debated point. We undertook this study to check the hypothesis according to which remote cortical dysfunction could be responsible for the occurrence of neglect. Twenty-eight patients presenting with a right-sided subcortical stroke were studied. A neuropsychological battery of tests suitable for assessment of possible visuo-spatial neglect was performed as well as HMPAO SPECT. Neglect was observed in 15 cases out of 28. The lesion's site (at CT and/or MRI) did not allow discrimination between patients without neglect and patients with neglect. The latter however could be distinguished from the former by the presence of a remote decrease in cortical blood flow in the right temporo-parietal region. By suggesting that cortical involvement is necessary for the occurrence of neglect, the results were interpreted according to a network approach in which subcortical neglect is attributed to a cortical deprivation from afferent input in the posterior part of the brain.
因右侧深部半球病变导致的神经心理障碍的病理生理学仍是一个有争议的问题。我们开展这项研究以检验如下假设：即远隔皮质功能障碍可能是忽视症发生的原因。对28例右侧皮质下卒中患者进行了研究。进行了一套适用于评估可能存在的视觉空间忽视的神经心理学测试以及HMPAO单光子发射计算机断层扫描（SPECT）。28例患者中有15例观察到忽视症。病变部位（CT和/或MRI检查结果）无法区分无忽视症的患者和有忽视症的患者。然而，后者可通过右侧颞顶叶区域远隔皮质血流减少与前者相鉴别。通过提示皮质受累是忽视症发生所必需的，研究结果根据一种网络方法进行解释，即皮质下忽视症归因于大脑后部传入输入导致的皮质剥夺。
