远程皮质功能障碍是皮质下忽视的可能原因吗？一项局部脑血流研究。

Remote cortical dysfunction as a possible cause of subcortical neglect? A regional cerebral blood flow study.

作者信息

Hublet C, Demeurisse G, Paternot J, Colson C, Capon A

机构信息

Hôpital Universitaire Brugmann, Service de Revalidation Neurologique, Bruxelles, Belgique.

出版信息

Eur Neurol. 1995;35(5):254-8. doi: 10.1159/000117144.

DOI:10.1159/000117144

PMID:8542912

Abstract

Cortical remote effects of right deep-seated lesions were studied with two cerebral blood flow measurement methods (two-dimensional xenon-133 inhalation and 99mTc HMPAO SPECT) in a population of 13 right-handed stroke patients. A neuropsychological battery of tests suitable for assessment of possible visual neglect was performed. Neglect was present in 7 cases. A regional cortical hypoperfusion was observed in all patients. However, in neglect patients it was more extended and involved the right inferior parietal region suggesting a causal relationship between cortical dysfunction and neuropsychological deficit. This finding supports the model attributing neglect to a unilateral attention-arousal defect in a cortico-limbic-reticular loop.

摘要

采用两种脑血流量测量方法（二维氙-133吸入法和99mTc HMPAO单光子发射计算机断层扫描）对13例右利手脑卒中患者群体进行了右侧深部病变的皮质远隔效应研究。进行了一套适用于评估可能的视觉忽视的神经心理学测试。7例患者存在忽视症状。所有患者均观察到局部皮质灌注不足。然而，在忽视患者中，灌注不足范围更广，累及右侧顶下叶区域，提示皮质功能障碍与神经心理学缺陷之间存在因果关系。这一发现支持了将忽视归因于皮质-边缘-网状环路单侧注意力唤起缺陷的模型。