Klenoff B H, Goodman M L
J Laryngol Otol. 1977 Sep;91(9):751-6. doi: 10.1017/s0022215100084322.
Excised nasal polyps should be examined histologically for classification as to aetiological process. Recently a 'pseudosarcomatous' change was reported in nasal polyps. We reviewed one hundred excised polyps for mesenchymal atypicality and found a wide degree of mesenchymal atypicality in the majority of nasal polyps. Nasal and choanal inflammatory polyps are the most frequent nasal masses which the otolaryngologist has to treat. Surgical excision is frequently required to alleviate the nasal symptoms of polyps unresponsive to medical therapy. Excised nasal polyps should be examined histologically for classification as to possible aetiological mechanisms and to rule out neoplastic lesions (Shea, 1947). Smith, Echevarria, and McLelland (Smith, 1974) recently described 'pseudosarcomatous changes' in nasal polyps. This stimulated us to investigate our inflammatory nasal polyps for these histological changes. Causal observations demonstrated an impressive number of inflammatory polyps with varying amounts of atypical mesenchymal stroma cells. To quantitate these alterations, we reviewed the histological slides from one hundred patients with excised inflammatory polyps and the results are the subject of this report.
切除的鼻息肉应进行组织学检查，以根据病因学过程进行分类。最近有报道称鼻息肉中出现了“假肉瘤样”改变。我们检查了100例切除的息肉的间质性异型性，发现大多数鼻息肉存在广泛程度的间质性异型性。鼻和后鼻孔炎性息肉是耳鼻喉科医生必须治疗的最常见的鼻部肿物。对于药物治疗无效的息肉，常常需要手术切除以缓解鼻部症状。切除的鼻息肉应进行组织学检查，以确定可能的病因机制并排除肿瘤性病变（Shea，1947年）。Smith、Echevarria和McLelland（Smith，1974年）最近描述了鼻息肉中的“假肉瘤样改变”。这促使我们对炎性鼻息肉进行这些组织学改变的研究。因果观察显示，大量炎性息肉存在数量不等的非典型间质性基质细胞。为了量化这些改变，我们检查了100例切除炎性息肉患者的组织学切片，结果为本报告的主题。
