Faergemann J, Hersle K, Nordin P
Department of Dermatology, Sahlgrenska University Hospital, Gothenburg, Sweden.
Dermatology. 1997;194 Suppl 1:19-21. doi: 10.1159/000246178.
Pityriasis versicolor is a chronic superficial fungal disease usually located on the upper trunk, neck or upper arms. Terbinafine is an orally and topically active allylamine antifungal derivative with a broad antifungal spectrum. Several studies have documented the high activity of terbinafine (Lamisil) cream in the treatment of pityriasis versicolor, with cure rates of 79-100% after 2-4 weeks of treatment. Lamisil emulsion gel (Lamisil DermGel) is a new topical formulation that remains in the skin in high concentrations for several months after just 1 week of application. Recently, in a prospective, double-blind, placebo-controlled, randomised, parallel-group, comparative, multicentre study, we have treated patients with pityriasis versicolor with either terbinafine 1% emulsion gel (Lamisil DermGel) or placebo gel. Sixty-one patients were included, 31 in the Lamisil DermGel group and 30 in the placebo gel group. The gel was applied once daily for 7 days and the patients were followed up for 8 weeks. Twenty-eight patients in the active and 29 patients in the placebo group were evaluable for efficacy. Using the intent-to-treat efficacy analysis, 21/28 (75%) were cured in the Lamisil-DermGel-treated group compared to 4/29 (14%) in the placebo group. No side-effects were seen. In conclusion, Lamisil DermGel was well tolerated and superior to placebo in the treatment of pityriasis versicolor when applied once daily for 7 days.
花斑糠疹是一种慢性浅表真菌病，通常发生于上躯干、颈部或上臂。特比萘芬是一种口服和外用均有效的烯丙胺类抗真菌衍生物，抗菌谱广。多项研究证实，特比萘芬（兰美抒）乳膏治疗花斑糠疹的活性高，治疗2-4周后的治愈率为79%-100%。兰美抒乳胶（兰美抒皮肤乳胶）是一种新型外用制剂，仅应用1周后就能在皮肤中保持高浓度数月。最近，在一项前瞻性、双盲、安慰剂对照、随机、平行组、比较性多中心研究中，我们用1%特比萘芬乳胶（兰美抒皮肤乳胶）或安慰剂凝胶治疗花斑糠疹患者。共纳入61例患者，兰美抒皮肤乳胶组31例，安慰剂凝胶组30例。凝胶每天应用1次，共7天，对患者随访8周。活性药物组28例患者和安慰剂组29例患者可进行疗效评估。采用意向性疗效分析，兰美抒皮肤乳胶治疗组21/28（75%）治愈，而安慰剂组为4/29（14%）。未观察到副作用。总之，兰美抒皮肤乳胶耐受性良好，每天应用1次、共7天时，治疗花斑糠疹优于安慰剂。
