Vermeer B J, Staats C C
Department of Dermatology, University Medical Center, Leiden, The Netherlands.
Dermatology. 1997;194 Suppl 1:22-4. doi: 10.1159/000246179.
A prospective randomised placebo-controlled double-blind study was designed to investigate whether topical terbinafine 1% solution is an effective treatment for subjects with pityriasis versicolor. The intention-to-treat population consisted of 110 subjects. The number of subjects who received terbinafine 1% solution was 76 and the number who received placebo was 34; treatments were given twice a day for 1 week. The primary efficacy variables were categorised at weeks 1, 2, 4 and 8. Eight weeks after the start of therapy, 81% of the subjects using terbinafine solution and 41% of those receiving placebo had a negative mycological examination (p < 0.001). A clinical effect of treatment was recorded in 72% of the subjects using terbinafine 1% solution and 26% of those receiving placebo (p < 0.001). We conclude that terbinafine 1% solution is an effective and safe local treatment modality for pityriasis versicolor.
一项前瞻性随机安慰剂对照双盲研究旨在调查1%特比萘芬溶液局部用药对花斑糠疹患者是否为有效治疗方法。意向性治疗人群包括110名受试者。接受1%特比萘芬溶液治疗的受试者有76名，接受安慰剂治疗的有34名；治疗每天给药两次，持续1周。主要疗效变量在第1、2、4和8周进行分类。治疗开始8周后，使用特比萘芬溶液的受试者中有81%真菌学检查呈阴性，接受安慰剂治疗的受试者中这一比例为41%（p<0.001）。使用1%特比萘芬溶液治疗的受试者中有72%记录到治疗的临床效果，接受安慰剂治疗的受试者中这一比例为26%（p<0.001）。我们得出结论，1%特比萘芬溶液是治疗花斑糠疹的一种有效且安全的局部治疗方式。
