Shimizu M, Nakayama M
Department of Pathology, Kawasaki Medical School, Okayama, Japan.
J Clin Pathol. 1997 Feb;50(2):171-2. doi: 10.1136/jcp.50.2.171.
A case of endometrial ossification in a 62 year old woman is reported. The patient presented with increased vaginal discharge. On transvaginal ultrasonography, a hyperechoic area within the uterine cavity, suggestive of an intrauterine foreign body, was noted. Histological examination of the endometrial curettage showed mature bone with neutrophilic infiltration. There was no evidence of malignancy. Endometrial ossification in postmenopausal women is very rare; most women presenting with this condition are between 20 and 40 years of age. Therefore, clinicians should consider the possibility of endometrial ossification as a differential diagnosis of intrauterine foreign body on ultrasound, even in older patients. In addition, pathologists should be aware of this rare entity to avoid a misdiagnosis of malignant mixed müllerian tumor in the endometrial curettage specimen, which may result in unnecessary hysterectomy.
报道了一例62岁女性子宫内膜骨化的病例。该患者表现为阴道分泌物增多。经阴道超声检查发现宫腔内有一高回声区，提示宫内异物。子宫内膜刮宫组织学检查显示成熟骨组织伴有中性粒细胞浸润。无恶性证据。绝经后女性的子宫内膜骨化非常罕见；大多数患有这种疾病的女性年龄在20至40岁之间。因此，临床医生即使在老年患者中，也应考虑子宫内膜骨化作为超声诊断宫内异物鉴别诊断的可能性。此外，病理学家应了解这种罕见实体，以避免在子宫内膜刮宫标本中误诊为恶性混合性苗勒管肿瘤，这可能导致不必要的子宫切除术。
