白芷根中的组胺释放效应物。
Histamine-release effectors from Angelica dahurica var. dahurica root.
作者信息
Kimura Y, Okuda H
机构信息
2nd Department of Medicinal Biochemistry, School of Medicine, Ehime University, Japan.
出版信息
J Nat Prod. 1997 Mar;60(3):249-51. doi: 10.1021/np960407a.
Six compounds isolated from the EtOAc fraction of the dried roots of Angelica dahurica var. dahurica inhibited compound 48/80-induced histamine levels in mouse peritoneal cavity (in vivo). Bergapten, oxypeucedanin hydrate, and byakangelicin inhibited compound 48/80-induced histamine elevation at a dose of 25 mg/kg. Conversely, sec-O-acetylbyakangelicin [8-(2-acetoxy-3-hydroxy-3-methylbutoxy)-5-methoxypsoralenI enhanced compound 48/80-induced histamine elevation at a dose of 25 mg/kg, while phellopterin and oxypeucedanin had no effect.
从白芷变种干燥根的乙酸乙酯部位分离得到的六种化合物在小鼠腹腔内（体内）抑制了化合物48/80诱导的组胺水平。补骨脂素、氧化前胡素水合物和白当归素在剂量为25mg/kg时抑制了化合物48/80诱导的组胺升高。相反，异欧前胡素[8-(2-乙酰氧基-3-羟基-3-甲基丁氧基)-5-甲氧基补骨脂素]在剂量为25mg/kg时增强了化合物48/80诱导的组胺升高，而浙贝母素和氧化前胡素则没有作用。
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