来自毛叶轮环藤的细胞毒性和抗疟双苄基异喹啉生物碱。

Cytotoxic and antimalarial bisbenzylisoquinoline alkaloids from Cyclea barbata.

作者信息

Lin L Z, Shieh H L, Angerhofer C K, Pezzuto J M, Cordell G A, Xue L, Johnson M E, Ruangrungsi N

机构信息

Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois, Chicago 60612.

出版信息

J Nat Prod. 1993 Jan;56(1):22-9. doi: 10.1021/np50091a004.

DOI:10.1021/np50091a004

PMID:8450318

Abstract

An alkaloid extract derived from the roots of Cyclea barbata demonstrated cytotoxic and antimalarial activities, and five bisbenzylisoquinoline alkaloids, (+)-tetrandrine [1], (-)-limacine [2], (+)-thalrugosine [3], (+)-homoaromoline [4], and (-)-cycleapeltine [5], were isolated as the active principles. The complete and unambiguous assignments of the 1H- and 13C-nmr data of these substances were made by 1D and 2D nmr techniques (COSY, phase-sensitive ROESY, HETCOR, and FLOCK).

摘要

从轮环藤根中提取的生物碱提取物具有细胞毒性和抗疟活性，从中分离出五种双苄基异喹啉生物碱，即（+）-粉防己碱[1]、（-）-青藤碱[2]、（+）-锡生藤碱[3]、（+）-高阿罗莫灵[4]和（-）-轮环藤宁碱[5]作为活性成分。通过一维和二维核磁共振技术（COSY、相敏ROESY、HETCOR和FLOCK）对这些物质的1H-和13C-核磁共振数据进行了完整且明确的归属。