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生物体液中甲基多巴的荧光测定法。

Fluorometric determination of methyldopa in biological fluids.

作者信息

Kim B K, Koda R T

出版信息

J Pharm Sci. 1977 Nov;66(11):1632-4. doi: 10.1002/jps.2600661135.

DOI:10.1002/jps.2600661135
PMID:915747
Abstract

A fluorometric method for the analysis of methyldopa, based on the formation of a fluorophore after oxidation and rearrangement, is described. The drug is isolated from biological fluids by adsorption on alumina and elution with an organic solvent. Fluoresence is linear from 0.1 to 1.5 microgram of methyldopa/ml. The assay has a lower limit of sensitivity of 100 ng/ml and is suitable for pharmacokinetic studies following therapeutic doses in animals and humans.

摘要

本文描述了一种基于氧化和重排后形成荧光团来分析甲基多巴的荧光法。该药物通过吸附在氧化铝上并以有机溶剂洗脱从生物流体中分离出来。荧光强度在甲基多巴浓度为0.1至1.5微克/毫升时呈线性关系。该测定法的灵敏度下限为100纳克/毫升，适用于动物和人类治疗剂量后的药代动力学研究。

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1
Fluorometric determination of methyldopa in biological fluids.生物体液中甲基多巴的荧光测定法。
J Pharm Sci. 1977 Nov;66(11):1632-4. doi: 10.1002/jps.2600661135.
2
Determination of methyldopa in pharmaceutical dosage forms and biological fluids based on oxidation at the tubular carbon electrode.基于管状碳电极上的氧化反应测定药物剂型和生物流体中的甲基多巴。
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The fluorometric assay of catecholamines and related compounds: improvements and extensions to the hydroxyindole technique.儿茶酚胺及相关化合物的荧光测定法：对羟基吲哚技术的改进与扩展
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A rapid high performance liquid chromatographic determination of methyldopa in human serum with fluorescence detection and alumina extraction: application to a bioequivalence study.采用荧光检测和氧化铝萃取的高效液相色谱法快速测定人血清中的甲基多巴：在生物等效性研究中的应用
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First report for voltammetric determination of methyldopa in the presence of folic acid and glycine.首次报告在叶酸和甘氨酸存在下伏安法测定甲基多巴。
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Colorimetric assay of methyldopa bulk drug and tablets as its Fe(III) complex.
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Adsorptive stripping voltammetry determination of methyldopa on the surface of a carboxylated multiwall carbon nanotubes modified glassy carbon electrode in biological and pharmaceutical samples.在生物和药物样品中，通过在羧基化多壁碳纳米管修饰的玻碳电极表面上的吸附溶出伏安法测定甲基多巴。
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A reliable and simple method for simultaneous determination of DOPA and 3-O-methyldopa in plasma and brain.
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Extemporaneous preparation of methyldopa in two syrup vehicles.甲基多巴在两种糖浆载体中的临时制剂。
Am J Hosp Pharm. 1975 Aug;32(8):817-21.
10
[Fluorometric determination of methyldopa in blood].
Pharm Weekbl. 1971 May 14;106(20):385-91.

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