Reynolds C, Tazelaar H D, Edwards W D
Division of Anatomic Pathology, Mayo Clinic, Rochester, MN 55905, USA.
Hum Pathol. 1997 May;28(5):601-6. doi: 10.1016/s0046-8177(97)90083-6.
Eleven cases of poorly characterized nonneoplastic endocardially based intracavitary cardiac masses have been seen at the Mayo Clinic between 1965 and 1994. They occurred in 7 women and 4 men from age 16 to 75 years (mean, 52 years). The patients presented with a wide variety of symptoms and underlying diseases. The lesions were diagnosed as a primary cardiac neoplasm in 6 of 8 patients having echocardiography. Surgical excision was the treatment of choice in 10 patients; the 11th patient died of noncardiac causes 30 days after the mass was discovered. Grossly, the lesions were firm, yellow-white, and partially calcified, and arose in any of the four chambers. Microscopically, all lesions were characterized by nodular calcium in a background of degenerating blood elements and chronic inflammation. All patients had a benign course relative to their cardiac lesion. Repeat echocardiogram in two patients showed residual calcium in the region of the initial tumor. Although these lesions may represent calcified thrombi, the clinical presentation did not suggest thrombosis as the most likely explanation for their occurrence. Based on the combined clinical presentation and microscopic appearance, the authors propose the descriptive name calcified amorphous tumors (cardiac CAT) to describe this group to nonneoplastic cardiac masses.
1965年至1994年间，梅奥诊所共收治了11例特征不明的非肿瘤性心腔内心脏肿物患者。患者年龄在16岁至75岁之间（平均52岁），其中女性7例，男性4例。患者表现出各种各样的症状和基础疾病。在8例接受超声心动图检查的患者中，有6例被诊断为原发性心脏肿瘤。10例患者选择手术切除治疗；第11例患者在肿物发现30天后死于非心脏原因。大体上，肿物质地坚硬，呈黄白色，部分钙化，可发生于四个心腔中的任何一个。显微镜下，所有肿物的特征均为在退变血液成分和慢性炎症背景下出现结节状钙盐沉积。相对于心脏肿物而言，所有患者病情均呈良性经过。两名患者复查超声心动图显示原肿瘤部位有残留钙盐。尽管这些肿物可能代表钙化血栓，但临床表现并不提示血栓形成是其发生的最可能原因。基于临床表现和显微镜下表现，作者提出用“钙化无定形肿瘤（心脏CAT）”这一描述性名称来描述这组非肿瘤性心脏肿物。
