4-Substituted semicarbazones of mono- and dichlorobenzaldehydes as antihypertensive agents.
作者信息
Warren J D, Woodward D L, Hargreaves R T
出版信息
J Med Chem. 1977 Nov;20(11):1520-1. doi: 10.1021/jm00221a034.
PMID:915918
Abstract
Twelve 4-substituted semicarbazone derivatives of o- and p-chloro- as well as 2,6-dichlorobenzaldehyde were synthesized and investigated for antihypertensive activity in spontaneously hypertensive rats. Several of the compounds synthesized (viz. 1, 6, 7, and 15) exhibited potent antihypertensive effects when orally administered. The same compounds were not hypotensive in the normotensive dog.
摘要
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