Friedman-Mor Z, Chalon J, Turndorf H, Orkin L R
J Trauma. 1977 Nov;17(11):829-34. doi: 10.1097/00005373-197711000-00002.
Significantly elevated numbers of iron laden histiocytes have been shown to appear in the tracheobronchial secretions of subjects in hemorrhagic shock and in patients undergoing open heart-surgery during cardiopulmonary bypass (3,4). Abnormal heme pigments have also been demonstrated in the serum of dogs bled to hemorrhagic shock (6) and have been felt to be toxic. Because the ingestion of abnormal heme pigments by histiocytes may be part of a defense mechanism, we have attempted to correlate the percentage of iron laden histiocytes found in the tracheobronchial secretions of patients in hemorrhagic shock (Prussian blue method) with the presence of degradation of products of hemoglobin found in their serum by scanning spectrophotometry. There were, generally speaking, few iron laden histiocytes when hemoglobin degradation was advanced, and always numerous iron laden histiocytes when abnormal heme pigments were absent or spectrophotometric findings revealed minor degrees of degradation. Our findings probably reflect the process in the reticuloendothelial systems which eliminates toxic products accumulating in the circulation in low-flow states.
研究表明，在失血性休克患者以及体外循环下心内直视手术患者的气管支气管分泌物中，含铁血组织细胞数量显著增多(3,4)。在失血性休克的犬类血清中也证实存在异常血红素色素(6)，并且认为这些色素具有毒性。由于组织细胞摄取异常血红素色素可能是一种防御机制的一部分，我们试图通过扫描分光光度法，将失血性休克患者气管支气管分泌物中含铁血组织细胞的百分比(普鲁士蓝法)与血清中血红蛋白降解产物的存在情况进行关联。一般来说，当血红蛋白降解进展时，含铁血组织细胞很少；而当不存在异常血红素色素或分光光度法结果显示降解程度较小时，总是存在大量含铁血组织细胞。我们的研究结果可能反映了网状内皮系统清除低流量状态下循环中积累的有毒产物的过程。
