Beck J G, Shipherd J C
Department of Psychology, State University of New York at Buffalo 14260, USA.
Behav Res Ther. 1997 Jun;35(6):551-7. doi: 10.1016/s0005-7967(97)00010-7.
In order to explore the mechanism of action of interoceptive exposure, 12 Panic Disorder (PD) patients were presented with two sessions of repeated CO2 inhalation. Two distinct patterns of responding were noted. The first pattern was described as habituation of fear (n = 6). These patients showed decrements in pre- and post-inhalation anxiety during both sessions (with more rapid decline during session 2), as well as spontaneous recovery of fear at the onset of session 2. The second pattern indicated fear sensitization. These patients showed relatively low levels of anticipatory anxiety preceding CO2 inhalation during both sessions but reported robust increases in fear following gas inhalation. The extent of this increase was slightly less during session 2 relative to session I and did not appear to be mediated by cardiovascular arousal, as both groups showed rapid HR habituation during both sessions. Results are discussed in light of current theories of PD and its treatment.
为了探究内感受暴露的作用机制，对12名惊恐障碍（PD）患者进行了两阶段的重复二氧化碳吸入试验。观察到两种不同的反应模式。第一种模式被描述为恐惧习惯化（n = 6）。这些患者在两个阶段的吸入前和吸入后焦虑水平均有所下降（在第二阶段下降更快），并且在第二阶段开始时恐惧自发恢复。第二种模式表明恐惧敏感化。这些患者在两个阶段的二氧化碳吸入前预期焦虑水平相对较低，但报告称吸入气体后恐惧显著增加。相对于第一阶段，第二阶段这种增加的程度略小，并且似乎不是由心血管唤醒介导的，因为两组在两个阶段心率均迅速习惯化。根据当前关于惊恐障碍及其治疗的理论对结果进行了讨论。
