Bozner P, Elkhalifa M Y
Department of Pathology, University of South Alabama Medical Center, Mobile 36617, USA.
South Med J. 1997 May;90(5):559-66. doi: 10.1097/00007611-199705000-00023.
Anaplastic large cell lymphoma (ALCL) is an uncommon non-Hodgkin's lymphoma in the general population as well as in HIV-infected patients. Ordinarily, ALCL expresses T-cell phenotype, but lymphoproliferative disorders derived from T cells rarely occur in acquired immunodeficiency syndrome (AIDS). We describe a white male homosexual with AIDS who had bilateral pleural effusions. Examination of the pleural fluid revealed ALCL positive for Ki-1 (CD30), LCA (CD45), UCHL-1 (CD45RO), CD43, CD3, and epithelial membrane antigen. The lymphoma was negative for the B-cell marker L26 (CD20) and for Leu-M1 (CD15). The T-cell origin was also confirmed by the monoclonal rearrangement of the T-cell receptor beta chain gene. A review of other cases of ALCL in HIV-positive individuals shows variability in clinical presentation and biologic behavior of this lymphoma type. It also points to the potential contribution of gene rearrangement studies for recognition of phenotype. In addition, the role of determination of the presence of t(2;5) and the corresponding gene product is discussed.
间变性大细胞淋巴瘤（ALCL）在普通人群以及HIV感染患者中都是一种罕见的非霍奇金淋巴瘤。通常，ALCL表达T细胞表型，但源自T细胞的淋巴增殖性疾病在获得性免疫缺陷综合征（AIDS）中很少发生。我们描述了一名患有AIDS的白人男性同性恋者，他有双侧胸腔积液。对胸腔积液的检查显示ALCL对Ki-1（CD30）、LCA（CD45）、UCHL-1（CD45RO）、CD43、CD3和上皮膜抗原呈阳性。该淋巴瘤对B细胞标志物L26（CD20）和Leu-M1（CD15）呈阴性。T细胞起源也通过T细胞受体β链基因的单克隆重排得到证实。对HIV阳性个体中其他ALCL病例的回顾显示，这种淋巴瘤类型的临床表现和生物学行为存在差异。它还指出了基因重排研究对表型识别的潜在贡献。此外，还讨论了确定t(2;5)的存在及其相应基因产物的作用。
