Dunphy C H, Collins B, Ramos R, Grosso L E
Department of Pathology, St. Louis University Health Sciences Center, Missouri, USA.
Diagn Cytopathol. 1998 Feb;18(2):113-7. doi: 10.1002/(sici)1097-0339(199802)18:2<113::aid-dc6>3.0.co;2-g.
We report a patient with acquired immunodeficiency syndrome with secondary pleural and pulmonary involvement by a CD30+ anaplastic large cell lymphoma (ALCL) that morphologically simulated metastatic adenocarcinoma. We describe the morphologic findings in order to heighten awareness that CD30+ ALCL may mimic metastatic adenocarcinoma in a body fluid or bronchial brushing and should be considered in the differential diagnosis. Primary body cavity based (PCBC) AIDS-related lymphoma is a relatively newly described disease entity with morphologic features bridging ALCL and large cell immunoblastic lymphoma with a CD30+ null immunophenotype. A morphology mimicking adenocarcinoma has not been previously described in this entity but should be considered in a patient with AIDS presenting exclusively with a serous effusion. Appropriate immunoperoxidase staining should aid in these differential diagnoses.
我们报告了一名获得性免疫缺陷综合征患者，其继发有CD30+间变性大细胞淋巴瘤（ALCL）累及胸膜和肺，形态上酷似转移性腺癌。我们描述这些形态学表现，以提高对以下情况的认识：CD30+ ALCL在体液或支气管刷片中可能酷似转移性腺癌，在鉴别诊断中应予以考虑。原发性体腔型（PCBC）艾滋病相关淋巴瘤是一种相对较新描述的疾病实体，其形态学特征介于ALCL和具有CD30+阴性免疫表型的大细胞免疫母细胞淋巴瘤之间。此前尚未描述过该实体中存在酷似腺癌的形态，但在仅表现为浆液性胸腔积液的艾滋病患者中应予以考虑。适当的免疫过氧化物酶染色有助于这些鉴别诊断。
