Dunner D L, Schmaling K B, Hendrickson H, Becker J, Lehman A, Bea C
Outpatient Psychiatry Center, Seattle, WA 98105-6099, USA.
Depression. 1996;4(1):34-41. doi: 10.1002/(SICI)1522-7162(1996)4:1<34::AID-DEPR4>3.0.CO;2-F.
We studied the effects of a fixed dose of fluoxetine (20 mg) or cognitive psychotherapy in a 16 week trial of patients with dysthymic disorder. More patients assigned to fluoxetine dropped out of the 16 week treatment (33%) than those assigned to cognitive therapy (9%), but this difference did not attain statistical significance. Both treatments showed improvement over baseline conditions at 8 weeks and further improvement at 16 weeks. There were no statistically significant group differences in treatment response. No follow-up data were collected so the enduring effects of the treatments are unknown. An optimal treatment for dysthymic disorder may be combined psychotherapy and pharmacotherapy for a longer period of time.
在一项针对心境恶劣障碍患者的为期16周的试验中，我们研究了固定剂量氟西汀（20毫克）或认知心理治疗的效果。与接受认知治疗的患者（9%）相比，更多接受氟西汀治疗的患者在16周治疗期内退出（33%），但这种差异未达到统计学显著性。两种治疗方法在8周时均较基线状况有所改善，并在16周时进一步改善。治疗反应方面不存在统计学显著的组间差异。未收集随访数据，因此治疗的持久效果未知。心境恶劣障碍的最佳治疗方法可能是较长时间的联合心理治疗和药物治疗。
