Skidmore S J, Collingham K E, Harrison P, Neilson J R, Pillay D, Milligan D W
Department of Haematology, Birmingham Heartlands and Solihull NHS Trust (Teaching), UK.
Blood. 1997 May 15;89(10):3853-6.
Hepatitis G virus (HGV) is a newly described virus that has been implicated in transfusion-associated hepatitis. The prevalence of HGV in a group of multitransfused patients with hematological malignancy was studied using a reverse transcription polymerase chain reaction technique. Transfusion histories and serum aspartate aminotransferase (AST) levels were recorded. HGV was detected in 29 of 60 (48%) patients. There was no difference in HGV positivity rates between those with normal AST levels and those with raised AST levels. Analysis of patients by treatment type showed that 20 of 33 (61%) patients who received a bone marrow transplantation procedure were HGV positive compared with 9 of 27 (33%) treated with conventional combination chemotherapy (P = .036) despite similar transfusion histories. There was no significant difference in HGV positivity between patients treated before the introduction of United Kingdom blood donor screening for hepatitis C virus antibody:18 of 39 (46%) and those treated after the introduction of screening 11 of 21 (52%). HGV infection appears to be extremely common in these patients; however, the clinical significance of these findings with respect to liver dysfunction is not yet clear.
庚型肝炎病毒（HGV）是一种新发现的病毒，与输血相关的肝炎有关。采用逆转录聚合酶链反应技术研究了一组多次输血的血液系统恶性肿瘤患者中HGV的流行情况。记录输血史和血清天冬氨酸转氨酶（AST）水平。60例患者中有29例（48%）检测到HGV。AST水平正常者与AST水平升高者的HGV阳性率无差异。按治疗类型分析患者发现，接受骨髓移植手术的33例患者中有20例（61%）HGV阳性，而接受传统联合化疗的27例患者中有9例（33%）HGV阳性（P = 0.036），尽管输血史相似。在英国对丙型肝炎病毒抗体进行献血者筛查之前接受治疗的患者中，HGV阳性率无显著差异：39例中有18例（46%），在引入筛查后接受治疗的患者中，21例中有11例（52%）。HGV感染在这些患者中似乎极为常见；然而，这些发现对于肝功能障碍的临床意义尚不清楚。
