Eugenia Q R, Ana Q R, Carmen M
Department of Microbiology, Faculty of Medicine, University of Granada, Spain.
Eur J Epidemiol. 2001;17(3):271-4. doi: 10.1023/a:1017916506897.
GBV-C/HGV has been demonstrated to be distributed worldwide with a prevalence in blood donors higher than HCV. This distribution in the general population probably requires an effective non-parenteral route of transmission. A previous study was performed to evaluate the presence of GBV-C/HGV in serum. Saliva, faeces and urine samples of 30 patients (15 males and 15 females) and 15 semen samples from patients whose serum gave a GBV-C/HGV RNA positive result were then tested by a sensitive polymerase chain reaction (PCR) test. Five semen supernatant samples (33.3%) tested positive--four of them belonged to HIV positive patients--and two saliva samples contained GBV-C/HGV sequences (6.6%)--one from a HIV-positive patient. An internal control was used to detect PCR nonspecific inhibitors in the samples. The data suggest possible non-parenteral routes of transmission from this virus. Its presence in body fluids other than serum has clinical implications other than possible hepatic damage that remain to be investigated.
庚型肝炎病毒（GBV-C/HGV）已被证实广泛分布于世界各地，在献血者中的流行率高于丙型肝炎病毒（HCV）。在普通人群中的这种分布情况可能需要一种有效的非肠道外传播途径。之前进行了一项研究以评估血清中GBV-C/HGV的存在情况。随后，对30名患者（15名男性和15名女性）的唾液、粪便和尿液样本以及血清GBV-C/HGV RNA检测呈阳性的患者的15份精液样本进行了灵敏的聚合酶链反应（PCR）检测。5份精液上清液样本（33.3%）检测呈阳性——其中4份属于HIV阳性患者——2份唾液样本含有GBV-C/HGV序列（6.6%）——其中1份来自一名HIV阳性患者。使用内部对照来检测样本中的PCR非特异性抑制剂。这些数据表明该病毒可能存在非肠道外传播途径。它在血清以外的体液中的存在除了可能导致肝损伤外，还有其他临床意义，有待进一步研究。
