Somers T h, Houben V, Goovaerts G, Govaerts P J, Offeciers F E
University Department of Oto-Rhino-Laryngology, Head and Neck Surgery, Sint-Augustinus Hospital, Antwerp-Wilrijk, Belgium.
Clin Otolaryngol Allied Sci. 1997 Apr;22(2):162-6. doi: 10.1046/j.1365-2273.1997.00006.x.
A histological study was performed on total human tympanic membranes with a central perforation. The specimens originated from 30 consecutive and unselected operations in which a total myringectomy was performed prior to reconstruction by means of a tympanic allograft. Beside excessive thickening of the tympanic membrane in 73%, all membranes showed other histological abnormalities: inflammation (97%), excessive fibrosis (97%), tympanosclerosis (80%), hyperkeratosis (83%), rete riges (43%) and epithelial inclusions (6%). Histological localisation of the muco-epithelial junction showed a medial position in 30%, with extensive middle ear invasion by squamous epithelium in 7%. The surgeon performing myringoplasty should keep these findings in mind and he should closely examine the medial side of the perforated tympanic membrane in order to remove any ingrowing epithelium that otherwise would be trapped.
对有中央穿孔的完整人鼓膜进行了组织学研究。标本来自连续30例未经挑选的手术，这些手术在通过鼓室同种异体移植重建之前均进行了全鼓膜切除术。除73%的鼓膜过度增厚外，所有鼓膜均显示出其他组织学异常：炎症（97%）、过度纤维化（97%）、鼓室硬化（80%）、角化过度（83%）、rete riges（43%）和上皮包涵体（6%）。黏膜上皮交界处的组织学定位显示30%位于内侧，7%有鳞状上皮广泛侵入中耳。进行鼓膜成形术的外科医生应牢记这些发现，并且应仔细检查穿孔鼓膜的内侧，以清除任何否则会被困住的内生上皮。
