van Rooijen N, Bakker J, Sanders A
Department of Cell Biology and Immunology, Faculty of Medicine, Vrije Universiteit, Amsterdam, The Netherlands.
Trends Biotechnol. 1997 May;15(5):178-85. doi: 10.1016/s0167-7799(97)01019-6.
Macrophages play an important role in host defense reactions, for example, by phagocytosis of particulate materials. This process also results in the rapid removal of targeting devices such as liposomes and adenovirus vectors and of non-autologous grafted cells and materials. Another aspect of macrophage function is their production and secretion of proinflammatory cytokines. Transient and organ-specific suppression of macrophage function by liposome-mediated manipulation has been shown to improve the efficacy of drug and gene targeting and to reduce the symptoms of inflammatory reactions.
巨噬细胞在宿主防御反应中发挥着重要作用，例如通过吞噬颗粒物质。这个过程还会导致靶向装置（如脂质体和腺病毒载体）以及非自体移植细胞和材料的快速清除。巨噬细胞功能的另一个方面是它们产生和分泌促炎细胞因子。脂质体介导的操作对巨噬细胞功能进行短暂和器官特异性的抑制已被证明可以提高药物和基因靶向的效果，并减轻炎症反应的症状。
