Morrow L A, Steinhauer S R, Condray R, Hodgson M
Department of Psychiatry, University of Pittsburgh School of Medicine, PA 15213, USA.
J Int Neuropsychol Soc. 1997 May;3(3):269-75.
Journeymen painters were evaluated with a comprehensive battery of neuropsychological tests and compared to demographically similar nonexposed controls. For painters, a cumulative exposure to solvents was estimated from a structured interview that derived an index based on lifetime exposure and exposure in the past year. Painters were tested either shortly after having painted or after an exposure-free interval. Significant between-group differences were found on a cluster of tests measuring learning and memory. Within the painter group, scores on the learning and memory tests were significantly related to the interaction of condition and exposure. That is, those painters who were tested soon after painting and who also had a higher overall lifetime exposure, performed worst on tests of learning and memory. These results are consistent with the view that neuropsychological function--particularly learning and memory--may be compromised in active workers with a history of chronic solvent exposure. Furthermore, both the chronicity of solvent exposure, as well as the acuteness of the exposure, are significant factors in cognitive performance.
对熟练油漆工进行了一系列全面的神经心理学测试，并与人口统计学特征相似的未接触对照组进行比较。对于油漆工，通过结构化访谈估计溶剂的累积暴露量，该访谈得出一个基于终生暴露和过去一年暴露情况的指数。油漆工在油漆后不久或经过无暴露间隔后接受测试。在一组测量学习和记忆的测试中发现了显著的组间差异。在油漆工组中，学习和记忆测试的分数与测试条件和暴露的相互作用显著相关。也就是说，那些在油漆后不久接受测试且终生总体暴露量较高的油漆工，在学习和记忆测试中的表现最差。这些结果与以下观点一致，即神经心理功能——尤其是学习和记忆——可能在有慢性溶剂暴露史的在职工人中受到损害。此外，溶剂暴露的慢性程度以及暴露的急性程度都是认知表现的重要因素。
