Liabeuf A, Faivre J
Faculté de Médecine, Dijon, France.
Eur J Cancer Prev. 1997 Feb;6(1):24-30. doi: 10.1097/00008469-199702000-00005.
The purpose of this study was to examine the change in incidence pattern of oesophageal cancer in the Côte-d'Or region (Burgundy, France). Data from the population-based cancer registry were used to study time trends between 1976 and 1993, according to sex, place of residence, subsite and histology. There was a non-significant increase in incidence of oesophageal cancer, by an average of +1.0% [confidence interval:-0.7; +2.8] per year in men and +2.0% [CI: -3.0; +6.9] in women. In men, variations in incidence were minor according to subsite and place of residence, among the six age groups studied. In contrast, there were important changes among histological types. Rates of squamous cell carcinoma remained stable, but those of adenocarcinoma increased significantly (P < 0.001). They represented 5.6% of known histological types, between 1976 and 1987, and 20.1% in 1991-3. Similar trends were observed in women. This rising incidence of adenocarcinomas, observed later than in the UK or the USA, started in 1987-90 and was particularly pronounced between 1991 and 1993. In view of this sharp increase in incidence of oesophageal adenocarcinomas, research on their aetiological determinants is urgently needed.
本研究旨在调查科多尔省（法国勃艮第）食管癌发病率模式的变化。基于人群的癌症登记数据被用于研究1976年至1993年间按性别、居住地、肿瘤部位和组织学分类的时间趋势。食管癌发病率有不显著的上升，男性平均每年上升1.0%[置信区间：-0.7；+2.8]，女性为2.0%[置信区间：-3.0；+6.9]。在男性中，在所研究的六个年龄组中，发病率根据肿瘤部位和居住地的变化较小。相比之下，组织学类型之间存在重要变化。鳞状细胞癌的发病率保持稳定，但腺癌的发病率显著上升（P<0.001）。在1976年至1987年间，腺癌占已知组织学类型的5.6%，而在1991 - 1993年为20.1%。在女性中也观察到类似趋势。这种腺癌发病率的上升比英国或美国出现得晚，始于1987 - 1990年，在1991年至1993年间尤为明显。鉴于食管腺癌发病率的急剧上升，迫切需要对其病因决定因素进行研究。
