Schimpl G, Pesendorfer P, Steinwender G, Feierl G, Ratschek M, Höllwarth M E
Department of Pediatric Surgery, University of Graz Medical School, Austria.
Eur Surg Res. 1997;29(3):187-94. doi: 10.1159/000129523.
In rats with chronic portal hypertension (PH) and common bile duct ligation (CBDL), significant ileal bacterial overgrowth, translocation of indigenous intestinal bacteria, a decrease in hepatic and ileal reduced glutathione (GSH) and an increase in ileal mucosal lipid peroxidation occur. alpha-Tocopherol (vitamin E) and ascorbic acid (vitamin C) treatment attenuated the incidence of bacterial translocation, improved hepatic and ileal GSH levels and decreased ileal mucosal lipid peroxidation. These results suggest that in chronic PH and CBDL oxidative processes in the liver and intestine play an important role for bacterial translocation.
在患有慢性门静脉高压（PH）和胆总管结扎（CBDL）的大鼠中，出现了显著的回肠细菌过度生长、肠道固有细菌移位、肝脏和回肠还原型谷胱甘肽（GSH）减少以及回肠黏膜脂质过氧化增加。α-生育酚（维生素E）和抗坏血酸（维生素C）治疗可降低细菌移位的发生率，提高肝脏和回肠的GSH水平，并减少回肠黏膜脂质过氧化。这些结果表明，在慢性PH和CBDL中，肝脏和肠道的氧化过程在细菌移位中起重要作用。
