Simpson M D, Lubman D I, Slater P, Deakin J F
School of Biological Sciences, Neuroscience Division, University of Manchester, Manchester, United Kingdom.
Biol Psychiatry. 1996 Jun 1;39(11):919-28. doi: 10.1016/0006-3223(95)00026-7.
We previously reported increased glutamatergic innervation in orbital frontal cortex in schizophrenia. In view of the evidence that one serotonin (5-HT) receptor, the 5-HT(1A) subtype, is associated with cortical glutamatergic neurons, we have used quantitative receptor autoradiography to measure the specific binding of the 5-HT(1A) receptor ligand [3H]8-OH-DPAT (2 nM) in sections of orbital frontal cortex taken from 18 control and 12 schizophrenic postmortem brains. Schizophrenic patients, as compared with controls, had increased 5-HT(1A) receptor binding in the three orbital frontal regions examined. These effects were pronounced in the male subgroup, and were most apparent in the outer cortical laminae. These data are consistent with the hypothesis that schizophrenia is associated with an abnormal glutamatergic afferent innervation of orbital frontal cortex.
我们之前报道过，精神分裂症患者眶额皮质中的谷氨酸能神经支配增加。鉴于有证据表明一种血清素（5-HT）受体，即5-HT（1A）亚型，与皮质谷氨酸能神经元有关，我们使用定量受体放射自显影技术，来测量取自18例对照和12例精神分裂症患者死后大脑的眶额皮质切片中5-HT（1A）受体配体[3H]8-羟基二丙胺（2 nM）的特异性结合。与对照组相比，精神分裂症患者在所检查的三个眶额区域中5-HT（1A）受体结合增加。这些效应在男性亚组中更为明显，并且在皮质外层最为显著。这些数据与精神分裂症与眶额皮质谷氨酸能传入神经支配异常有关的假说一致。
