Kozlovskiĭ V L, Mosin A E, Ivakina L V
Eksp Klin Farmakol. 1997 Jan-Feb;60(1):10-2.
The effect of diazepam (0.5 mg/kg) and calcium channel blockers on the behavior of rats in an "open field" was studied on a model of incomplete amputation of vibrissae. Diazepam, diltiazem (1 mg/kg), fendiline (1 mg/kg), and cinnarizine (1 mg/kg) stimulated motor activity of animals with amputated vibrissae. Nifedipine (0.5-5 mg/kg) and verapamil (0.5-5 mg/kg) were practically inactive in these tests. It is concluded that diltiazem, fendiline, and cinnarizine possess anxiolytic activity in this model. On the basis of the results obtained, the methods for studying the anxiolytic activity on animals are discussed.
在触须不完全切断模型上，研究了地西泮（0.5毫克/千克）和钙通道阻滞剂对大鼠在“旷场”中行为的影响。地西泮、地尔硫䓬（1毫克/千克）、芬地林（1毫克/千克）和桂利嗪（1毫克/千克）刺激了触须被切断动物的运动活动。硝苯地平（0.5 - 5毫克/千克）和维拉帕米（0.5 - 5毫克/千克）在这些试验中几乎没有活性。得出的结论是，在该模型中地尔硫䓬、芬地林和桂利嗪具有抗焦虑活性。基于所获得的结果，讨论了在动物身上研究抗焦虑活性的方法。
