Filipets N D
Eksp Klin Farmakol. 1997 Jan-Feb;60(1):40-1.
It was demonstrated in experiments on albino rats that under the effect of nifedipine and verapamil the increase in the excretion of electrolytes and water by the kidneys is accompanied with a rise in the natriuretic hormone (NUH) content in blood plasma and urine. This causes the renal effects of the drugs under study. The sensitivity of the kidneys to NUH increases in this case.
在对白化大鼠的实验中表明,在硝苯地平和维拉帕米的作用下,肾脏对电解质和水的排泄增加,同时血浆和尿液中利钠激素(NUH)含量升高。这导致了所研究药物的肾脏效应。在这种情况下,肾脏对NUH的敏感性增加。