Muramori F, Kinoshita H, Kobayashi K, Fukutani Y, Miyazu K, Hayashi M, Aoki T, Miura Y, Harada K, Koshino Y
Department of Neuropsychiatry, Kanazawa University School of Medicine, Japan.
No To Shinkei. 1997 May;49(5):449-53.
A 36-year-old woman who had been in complete remission after bone marrow transplantation against her leukemia presented with visual disturbance and cerebellar signs. She showed unusual involuntary movement as if she rolled a ball of string, and died two months after the onset of illness. Necropsy revealed hemorrhagic and necrotic lesions in the thalamus, basal ganglia, cerebellar dentate nucleus, superior colliculus, midbrain pretectum and red nucleus, and mucor mycelia were numerously found. HSV-2 immunoreactivity was found in both astroglial and oligodendroglial perikaraya. These hemorrhagic-necrotic lesions were partly associated with HSV-2 infection, but it was difficult to discriminate those from mucormycotic lesions. The unusual involuntary movement was considered to be due to basal ganglia lesions. This case was double infection by mucor mycelia and HSV 2, and clinicopathological consideration was described.
