Sakurada T, Kohno H, Tadano T, Kisara K
Jpn J Pharmacol. 1977 Jun;27(3):453-60. doi: 10.1254/jjp.27.453.
Pharmacological actions of spermidine (SPD) and spermine (SPM) in mice given these polyamines by intracerebral injection (i.c.) were investigated. The spontaneous motor activity (SMA) assessed by the photocell counter method did not change immediately following injection of 80 mug SPD, but was enhanced 24 hours after the injection of 40 or 80 mug. A significant decrease of SMA was not immediately evident after the administration of 40 mug SPM but was demonstrated 24 hours later. Mice given single doses of 20 mug SPD exhibited increase in weight gain and those given 40 mug showed no significant difference, whereas a conspicuous decrease in weight occurred in mice given 80 mug of SPD. The body weights of mice given single doses of 10 mug SPM remained much the same, while significant weight losses occurred in both the SPM 20 mug and 40 mug dosed groups. There was a significant prolongation of pentobarbital induced sleep 6 days after the injection of high doses of SPD or SPM. Similar prolongation of sleeping time was also evident 30 minutes after the injection of SPM. A maximal hypothermic response with a fall by about 1 degree C was observed immediately following injection of 80 mug of SPD and 24 hours after the injection of 40 mug SPM, respectively.
研究了通过脑内注射（i.c.）给予亚精胺（SPD）和精胺（SPM）的小鼠中这些多胺的药理作用。采用光电计数器法评估的自发运动活动（SMA）在注射80μg SPD后立即未发生变化，但在注射40或80μg后24小时增强。给予40μg SPM后，SMA并未立即出现明显下降，但在24小时后出现。单次给予20μg SPD的小鼠体重增加，给予40μg的小鼠无显著差异，而给予80μg SPD的小鼠体重显著下降。单次给予10μg SPM的小鼠体重基本保持不变，而给予20μg和40μg SPM剂量组的小鼠均出现显著体重减轻。注射高剂量的SPD或SPM 6天后，戊巴比妥诱导的睡眠时间显著延长。注射SPM 30分钟后，睡眠时间也有类似的延长。分别在注射80μg SPD后立即和注射40μg SPM后24小时观察到最大体温降低反应，体温下降约1℃。
