Anderson D J, Shaw G G
Br J Pharmacol. 1974 Oct;52(2):205-11. doi: 10.1111/j.1476-5381.1974.tb09701.x.
1 Intravenous injection of rabbits with the polyamines spermine (10-30 mg/kg) and spermidine (50-90 mg/kg) produced hyperglycaemia.2 Given by intraventricular injection, spermine and spermidine gave rise to hyperglycaemia in doses 250-500 times smaller than those effective intravenously.3 Intraventricular injections of the polyamines also produced hyperglycaemia in rats. Adrenal demedullation abolished the response.4 In the rabbit, the hyperglycaemia resulting from intraventricular injection of polyamines was abolished in reserpine-treated animals. Anaesthesia had no effect on the response unless accompanied by anoxia, when the response was potentiated.5 Intracisternal injections of the polyamines in rabbits were less effective than intraventricular injections in that doses about four times larger were required to elicit an equivalent response.
给兔子静脉注射多胺类物质精胺（10 - 30毫克/千克）和亚精胺（50 - 90毫克/千克）会导致血糖过高。
通过脑室内注射给予时，精胺和亚精胺产生血糖过高所需的剂量比静脉注射有效剂量小250 - 500倍。
脑室内注射多胺类物质也会使大鼠出现血糖过高。肾上腺髓质切除消除了这种反应。
在兔子中，经利血平处理的动物，脑室内注射多胺类物质所导致的血糖过高现象消失。麻醉对该反应无影响，除非伴有缺氧，此时反应会增强。
兔脑池内注射多胺类物质的效果不如脑室内注射，因为引发同等反应所需的剂量大约要大四倍。
