Sakurada T, Kisara K
Jpn J Pharmacol. 1978 Feb;28(1):125-32. doi: 10.1254/jjp.28.125.
Freely moving rats with chronically implanted electrodes were used and the electroencephalogram (EEG) from the occipital cortex and the dorsal hippocampus, the electromyogram (EMG) and the electrooculogram (EOG) were simultaneously recorded. The REM (rapid eye movement) sleep stage was significantly shortened without a marked change of the Non-REM sleep from the 24th to the 32nd hr following injection of 40 microgram of SPD. The waking stage significantly increased, and the Non-REM sleep and REM sleep markedly decreased immediately after the injection of 40 microgram of SPM to the 8th, and from the 24th to the 32nd hr. The amount of total sleep significantly shortened from the 72nd to the 80th hr following injection of 40 microgram of SPD. The administration of 40 microgram of SPM significantly reduced the amount of total sleep in every period measured for 8 hr. Marked change was observed from the 24th to the 32nd hr following injection of 100 microgram of PUT, and Non-REM sleep and total sleep produced a significant decrease. These results show that the intraventricular administration of polyamines including PUT inhibits the amount of normal sleep.
使用长期植入电极的自由活动大鼠，同时记录枕叶皮质和背侧海马的脑电图（EEG）、肌电图（EMG）和眼电图（EOG）。注射40微克SPD后第24至32小时，快速眼动（REM）睡眠阶段显著缩短，非快速眼动睡眠无明显变化。注射40微克SPM后即刻至第8小时以及第24至32小时，清醒阶段显著增加，非快速眼动睡眠和快速眼动睡眠显著减少。注射40微克SPD后第72至80小时，总睡眠时间显著缩短。注射40微克SPM显著减少了所测量的8小时每个时间段的总睡眠时间。注射100微克PUT后第24至32小时观察到明显变化，非快速眼动睡眠和总睡眠显著减少。这些结果表明，脑室内注射包括PUT在内的多胺会抑制正常睡眠量。
