Pedersen E M, Agerbaek M, Kristensen I B, Yoganathan A P
Department of Cardiothoracic and Vascular Surgery, Skejby Sygehus, Aarhus University Hospital, Denmark.
Eur J Vasc Endovasc Surg. 1997 May;13(5):443-51. doi: 10.1016/s1078-5884(97)80171-2.
To study the correlation between wall shear stress and early atherosclerotic lesions in the abdominal aorta.
Blinded histomorphometric studies. Comparison with in vitro data.
Abdominal aortic haemodynamics were simulated in a realistic pulsatile flow model. Abdominal aortas from 10 young adults with no signs of atherosclerotic disease were obtained during autopsy.
Quantitative wall shear stresses were measured at rest and exercise in one suprarenal and two infrarenal positions using laser Doppler anemometry. Intimal thickening indices were measured blindly at the corresponding locations using histomorphometric methods, and compared to wall shear stress variables using linear regression analysis.
Intimal thickness index increased significantly with age. Intimal thickness index was significantly lower in the suprarenal than the infrarenal aorta, and higher at the distal posterior vessel wall compared to the anterior wall. Intimal thickness index correlated significantly with mean, minimum and oscillating wall shear stresses measured at rest.
Intimal thickness in the undiseased abdominal aorta correlated significantly with mean, minimum and oscillating wall shear stresses at rest measured in a pulsatile flow model. No correlations were found with maximum shear stress parameters. Exercise changed the local wall shear stresses away from the characteristics associated with intimal thickness index.
研究腹主动脉壁切应力与早期动脉粥样硬化病变之间的相关性。
盲法组织形态计量学研究。与体外数据进行比较。
在逼真的脉动血流模型中模拟腹主动脉血流动力学。从10例无动脉粥样硬化疾病迹象的年轻成年人尸检中获取腹主动脉。
使用激光多普勒血流仪在一个肾上腺上和两个肾上腺下位置静息和运动时测量定量壁切应力。使用组织形态计量学方法在相应位置盲法测量内膜增厚指数，并使用线性回归分析将其与壁切应力变量进行比较。
内膜厚度指数随年龄显著增加。肾上腺上主动脉的内膜厚度指数显著低于肾上腺下主动脉，且与前壁相比，后壁远端的内膜厚度指数更高。内膜厚度指数与静息时测量的平均、最小和振荡壁切应力显著相关。
在脉动血流模型中，未患病腹主动脉内膜厚度与静息时的平均、最小和振荡壁切应力显著相关。未发现与最大切应力参数相关。运动改变了局部壁切应力，使其偏离了与内膜厚度指数相关的特征。
