血液的非牛顿特性对人类动脉粥样硬化右冠状动脉壁面剪应力的影响。

Influence of non-Newtonian properties of blood on the wall shear stress in human atherosclerotic right coronary arteries.

作者信息

Liu Biyue, Tang Dalin

机构信息

Department of Mathematics, Monmouth University, West Long Branch, NJ 07764, USA.

出版信息

Mol Cell Biomech. 2011 Mar;8(1):73-90. doi: 10.3970/mcb.2011.008.073.

The objective of this work is to investigate the effect of non-Newtonian properties of blood on the wall shear stress (WSS) in atherosclerotic coronary arteries using both Newtonian and non-Newtonian models. Numerical simulations were performed to examine how the spatial and temporal WSS distributions are influenced by the stenosis size, blood viscosity, and flow rate. The computational results demonstrated that blood viscosity properties had considerable effect on the magnitude of the WSS, especially where disturbed flow was observed. The WSS distribution is highly non-uniform both temporally and spatially, especially in the stenotic region. The maximum WSS occurred at the proximal side of the stenosis, near the outer wall in the curved artery with no stenosis. The lumen area near the inner wall distal to the stenosis region experienced a lower WSS during the entire cardiac cycle. Among the factors of stenosis size, blood viscosity, and flow rate, the size of the stenosis has the most significant effect on the spatial and temporal WSS distributions qualitatively and quantitatively.

这项工作的目的是使用牛顿模型和非牛顿模型研究血液的非牛顿特性对动脉粥样硬化冠状动脉壁面剪应力（WSS）的影响。进行了数值模拟，以研究狭窄尺寸、血液粘度和流速如何影响壁面剪应力的空间和时间分布。计算结果表明，血液粘度特性对壁面剪应力的大小有相当大的影响，尤其是在观察到紊乱流动的地方。壁面剪应力分布在时间和空间上都是高度不均匀的，尤其是在狭窄区域。最大壁面剪应力出现在狭窄的近端，在没有狭窄的弯曲动脉中外壁附近。在整个心动周期中，狭窄区域远端内壁附近的管腔面积经历较低的壁面剪应力。在狭窄尺寸、血液粘度和流速这些因素中，狭窄尺寸在定性和定量方面对壁面剪应力的空间和时间分布影响最为显著。