Incerpi M H, Miller D A, Posen R, Byrne J D
Department of Obstetrics and Gynecology, LAC+USC Women's and Children's Hospital, USA.
Obstet Gynecol. 1997 May;89(5 Pt 2):826-8. doi: 10.1016/s0029-7844(97)81424-x.
Acute promyelocytic leukemia, a subset of acute myelogenous leukemia, is commonly associated with disseminated intravascular coagulation (DIC). All-trans retinoic acid is effective in the treatment of acute promyelocytic leukemia and may prevent an exacerbation of DIC. There is limited information, however, regarding the use of this agent in pregnancy.
A 29-year-old woman with acute promyelocytic leukemia and DIC at 24 weeks' gestation was treated successfully with all-trans retinoic acid during the pregnancy, delivering a viable, normal infant at 33 weeks.
This case illustrates the successful use of all-trans retinoic acid in pregnancy for the treatment of acute promyelocytic leukemia. With the combined, intensive efforts of the perinatal, neonatal, and hematology-oncology services, a favorable outcome was achieved.
急性早幼粒细胞白血病是急性髓系白血病的一个亚型，通常与弥散性血管内凝血（DIC）相关。全反式维甲酸对急性早幼粒细胞白血病有效，且可能预防DIC恶化。然而，关于该药物在孕期的使用信息有限。
一名29岁女性，孕24周时患急性早幼粒细胞白血病并伴有DIC，孕期接受全反式维甲酸治疗成功，于33周分娩出一名存活的正常婴儿。
该病例表明全反式维甲酸在孕期成功用于治疗急性早幼粒细胞白血病。在围产期、新生儿及血液肿瘤学多学科团队的共同努力下，取得了良好的结局。
