Kalueff A, Nutt D J
Department of Human and Animal Physiology, Faculty of Biology, Moscow State University, Russia.
Depress Anxiety. 1996;4(3):100-10. doi: 10.1002/(SICI)1520-6394(1996)4:3<100::AID-DA2>3.0.CO;2-K.
This review assesses the parallel literature on the role of gamma-aminobutyric acid (GABA) in memory and anxiety. We review historical and new data from both animal and human experimentation which have helped define the key role for this transmitter in both these mental states. By exploring the overlap in these conditions in terms of pharmacology, brain circuitry, and clinical phenomenology, we begin to develop a theory that the two conditions are intrinsically interrelated. The role of GABAergic agents in dissecting out and demonstrating this interrelationship and in pointing the way to future research is discussed.
本综述评估了关于γ-氨基丁酸（GABA）在记忆和焦虑中作用的相关文献。我们回顾了来自动物和人体实验的历史及新数据，这些数据有助于明确该神经递质在这两种心理状态中的关键作用。通过从药理学、脑回路和临床现象学方面探究这些情况的重叠之处，我们开始形成一种理论，即这两种情况本质上是相互关联的。文中还讨论了GABA能药物在剖析和证明这种相互关系以及为未来研究指明方向方面的作用。
