Hollander E, Greenwald S, Neville D, Johnson J, Hornig C D, Weissman M M
Columbia University, College of Physicians and Surgeons, New York, USA.
Depress Anxiety. 1996;4(3):111-9. doi: 10.1002/(SICI)1520-6394(1996)4:3<111::AID-DA3>3.0.CO;2-J.
This study investigated lifetime prevalence rates, demographic characteristics, childhood conduct disorder and adult antisocial features, suicide attempts, and cognitive impairment in individuals with obsessive-compulsive disorder (OCD) uncomplicated by or comorbid with any other psychiatric disorder. The data are from the NIMH Epidemiologic Catchment Area (ECA) study, and the current analyses compared subjects with uncomplicated OCD (no history of any other lifetime psychiatric disorder), comorbid OCD (with any other lifetime disorder), other lifetime psychiatric disorders, and no lifetime psychiatric disorders across these variables. OCD in its uncomplicated and comorbid form had significantly higher rates of childhood conduct symptoms, adult antisocial personality disorder problems, and of suicide attempts than did no or other disorders. Comorbid OCD subjects had higher rates of mild cognitive impairment on the Mini-Mental Status Exam than did subjects with other disorders. These findings suggest that a subgroup of OCD patients may have impulsive features, including childhood conduct disorder symptoms and an increased rate of suicide attempts; wider clinical attention to these outcomes is needed.
本研究调查了未合并或合并其他任何精神障碍的强迫症（OCD）患者的终生患病率、人口统计学特征、儿童期品行障碍和成人反社会特征、自杀未遂情况以及认知障碍。数据来自美国国立精神卫生研究所（NIMH）的流行病学集水区（ECA）研究，当前分析比较了单纯OCD患者（无任何其他终生精神障碍病史）、共病OCD患者（伴有任何其他终生障碍）、其他终生精神障碍患者以及无终生精神障碍患者在这些变量上的差异。单纯和共病形式的OCD患者在儿童期品行症状、成人反社会人格障碍问题以及自杀未遂率方面均显著高于无精神障碍或其他精神障碍患者。共病OCD患者在简易精神状态检查表上的轻度认知障碍发生率高于其他精神障碍患者。这些发现表明，一部分OCD患者可能具有冲动特征，包括儿童期品行障碍症状和自杀未遂率增加；需要对这些结果给予更广泛的临床关注。
