在唾液腺肿瘤中未发现爱泼斯坦-巴尔病毒和巨细胞病毒DNA。

No Epstein Barr and cytomegalovirus DNA found in salivary gland tumours.

作者信息

Kärjä V, Syrjänen K, Syrjänen S

机构信息

Department of Pathology, University of Kuopio, Finland.

出版信息

ORL J Otorhinolaryngol Relat Spec. 1997 Mar-Apr;59(2):97-9. doi: 10.1159/000276917.

DOI:10.1159/000276917

PMID:9166879

Abstract

A series of 219 (106 malignant and 113 benign) salivary gland tumours was investigated by in situ hybridisation (ISH) to detect Epstein-Barr-virus (EBV) and cytomegalovirus (CMV) DNA. Normal salivary gland did not show hybridisation signals for these viruses. Tumours presenting hybridisation signals in ductal and myoepithelial cells and 17 Warthin's tumours were further studied by PCR, but none of these tumours contained EBV or CMV DNA. Our series did not contain lymphoepithelial carcinomas, which are EBV-associated tumours. The results suggest that factors other than EBV or CMV are involved in carcinogenesis of primary salivary gland tumours.

摘要

通过原位杂交（ISH）检测爱泼斯坦-巴尔病毒（EBV）和巨细胞病毒（CMV）DNA，对219例唾液腺肿瘤（106例恶性和113例良性）进行了研究。正常唾液腺未显示这些病毒的杂交信号。对在导管和肌上皮细胞中呈现杂交信号的肿瘤以及17例沃辛瘤进一步进行了聚合酶链反应（PCR）研究，但这些肿瘤均未含有EBV或CMV DNA。我们的病例系列中不包括淋巴上皮癌，这是与EBV相关的肿瘤。结果表明，除EBV或CMV外的其他因素参与了原发性唾液腺肿瘤的致癌过程。