Wang H H, Chang Y H, Liu D M, Ho Y J
Department of Internal Medicine, China Medical College Hospital, Taichung, Taiwan.
Am J Chin Med. 1997;25(1):13-20. doi: 10.1142/S0192415X97000044.
Fifty-nine patients underwent consecutive colonoscopic examination with premedication of electroacupuncture analgesia (EA) were compared with conventional meperidine analgesia (MA) in pain relief and changes of neurotransmitters in serum. The results showed that analgesic efficacy of both groups were the same but with less side effects in the EA group (P < 0.01) especially in regard to dizziness. Serum concentration of beta-endorphin in both groups has a similar curve change at 4 different phases during colonoscopy. Serum concentration of epinephrine, norepinephrine, dopamine and cortisol showed no significant difference between these two groups. The analgesic effect of EA and MA during colonoscopic examination may be closely related to beta-endorphin production in serum.
对59例行结肠镜检查的患者进行了研究，将预先使用电针镇痛（EA）的患者与使用传统哌替啶镇痛（MA）的患者在疼痛缓解及血清神经递质变化方面进行了比较。结果显示，两组的镇痛效果相同，但EA组的副作用较少（P<0.01），尤其是头晕方面。两组血清β-内啡肽浓度在结肠镜检查的4个不同阶段有相似的曲线变化。两组间肾上腺素、去甲肾上腺素、多巴胺和皮质醇的血清浓度无显著差异。结肠镜检查期间EA和MA的镇痛作用可能与血清中β-内啡肽的产生密切相关。
