Mege J L, Maurin M, Capo C, Raoult D
Unité des Rickettsies, CNRS UPRESA 6020, Faculté de Médecine, Marseille, France.
FEMS Microbiol Rev. 1997 Apr;19(4):209-17. doi: 10.1111/j.1574-6976.1997.tb00298.x.
Although substantial progress occurred in the knowledge of Coxiella burnetii during the past years, the pathophysiology of Q fever is still obscure. Emerging evidence from clinical investigations suggested that certain disorders of cell-mediated immunity play a pivotal role in Q fever and especially in its chronic form. This review analyses the potential strategies that C. burnetii, a strictly intracellular pathogen, use to divert microbicidal mechanisms of macrophages and to depress protective T-cell mediated immunity. The role of monocytes in the induction of Q fever is specifically discussed.
尽管在过去几年里，人们对伯纳特立克次体的认识取得了重大进展，但Q热的病理生理学仍然不清楚。临床研究的新证据表明，细胞介导免疫的某些紊乱在Q热尤其是其慢性形式中起关键作用。本综述分析了严格胞内病原体伯纳特立克次体用来转移巨噬细胞杀菌机制和抑制保护性T细胞介导免疫的潜在策略。特别讨论了单核细胞在Q热诱导中的作用。
