Carraway K L, Weber J L, Unger M J, Ledesma J, Yu N, Gassmann M, Lai C
Department of Cell Biology, Harvard Medical School, Beth Israel Hospital, Boston, Massachusetts 02215, USA.
Nature. 1997 May 29;387(6632):512-6. doi: 10.1038/387512a0.
The neuregulins (NRGs) are a family of multipotent epidermal-growth-factor-like (EGF-like) factors that arise from splice variants of a single gene. They influence the growth, differentiation, survival and fate of several cell types. We have now discovered a set of new neuregulin-like growth factors, which we call neuregulin-2 (NRG-2): these are encoded by their own gene and exhibit a distinct expression pattern in adult brain and developing heart. Like NRG-1, the EGF-like domain of the new ligands binds to both the ErbB3- and ErbB4-receptor tyrosine kinases. However, NRG-2 stimulates different ErbB-receptor tyrosine-phosphorylation profiles from NRG-1. Our results indicate that NRG-1 and NRG-2 mediate distinct biological processes by acting at different sites in tissues and eliciting different biochemical responses in cells.
神经调节蛋白（NRGs）是一类多能的表皮生长因子样（EGF样）因子，由单个基因的剪接变体产生。它们影响多种细胞类型的生长、分化、存活和命运。我们现已发现一组新的神经调节蛋白样生长因子，我们将其称为神经调节蛋白-2（NRG-2）：它们由各自的基因编码，并在成体脑和发育中的心脏中表现出独特的表达模式。与NRG-1一样，新配体的EGF样结构域与ErbB3和ErbB4受体酪氨酸激酶结合。然而，NRG-2刺激产生的ErbB受体酪氨酸磷酸化谱与NRG-1不同。我们的结果表明，NRG-1和NRG-2通过作用于组织中的不同位点并在细胞中引发不同的生化反应来介导不同的生物学过程。
