Koziol T R, Jacob J T, Achari R G
J Pharm Sci. 1979 Sep;68(9):1135-8. doi: 10.1002/jps.2600680920.
The quantitative determinations of combinations of antihistamine and decongestant drugs including phenylephrine, dl-ephedrine, psi-ephedrine, phenylpropanolamine, pyrilamine, pheniramine, l-ephedrine, chlorpheniramine, brompheniramine, oxymetazoline, naphazoline, and antazoline contained in solid and liquid dosage forms are described. All active ingredients except the ephedrine optical isomers were separated from other ingredients with ion-paired high-pressure liquid chromatography. Manipulation of the mobile phase either by changing the hydroalcoholic ratio or by changing the alkyl chain length of the counterion (sulfonic acid) for achieving optimum separations is discussed. The method is simple, short, accurate, and precise.
描述了对固体和液体制剂中包含的抗组胺药和解充血药组合的定量测定，这些组合包括去氧肾上腺素、消旋麻黄碱、假麻黄碱、苯丙醇胺、吡苄明、非尼拉敏、L-麻黄碱、氯苯那敏、溴苯那敏、羟甲唑啉、萘甲唑啉和安他唑啉。除麻黄碱光学异构体之外的所有活性成分均通过离子对高压液相色谱法与其他成分分离。讨论了通过改变水醇比例或改变反离子（磺酸）的烷基链长度来操纵流动相以实现最佳分离。该方法简便、用时短、准确且精密。
