用于乳腺癌成像的 FDG 和 L-[1-11C]酪氨酸 PET 的标准化摄取值及代谢定量

Standardized uptake value and quantification of metabolism for breast cancer imaging with FDG and L-[1-11C]tyrosine PET.

作者信息

Kole A C, Nieweg O E, Pruim J, Paans A M, Plukker J T, Hoekstra H J, Schraffordt Koops H, Vaalburg W

机构信息

PET Center, Groningen University Hospital, The Netherlands.

出版信息

J Nucl Med. 1997 May;38(5):692-6.

PMID:9170429

Abstract

UNLABELLED

The aims of the study were to compare the value of L-[1-11C]tyrosine (TYR) and [IBF]fluoro-2-deoxy-D-glucose (FDG) as tumor tracers in patients with breast cancer, to investigate the correlation between quantitative values and standardized uptake values (SUVs) and to estimate the value of SUVs for the evaluation of therapy.

METHODS

Eleven patients with one or more malignant breast lesions and two patients with one or more benign breast tumors were studied with TYR and FDG. Doses of 300 MBq of TYR and 230 MBq of FDG were given intravenously. All PET sessions were performed using a Siemens ECAT 951/31 camera. Of 10 malignant tumors and the 3 benign lesions, glucose consumption and protein synthesis rate were quantified. All lesions were studied using SUVs based on body weight, body surface area and lean body mass, with and without correction for plasma glucose or tyrosine levels.

RESULTS

All malignant tumors were visualized with both FDG and TYR, but the visual contrast was better with FDG. Increased uptake of the tracers was seen in patients with fibrocystic tissue and complicated the visual assessment and the outlining of tumor tissue. Uptake in fibrocystic disease was more prominent with FDG than with TYR. No difference in tumor/nontumor ratio between the two tracers could be established. FDG showed a false-positive result in one benign lesion. No major differences between the SUVs as defined above were found, although the best correlation between glucose consumption and the SUV was observed when the SUV was based on body surface area and corrected for plasma glucose level (r = 0.85-0.87). The SUV based on lean body mass was found to correlate best with protein synthesis rate (r = 0.83-0.94).

CONCLUSION

In this group of patients, TYR appears to be a better tracer than FDG for breast cancer imaging, because of lower uptake in fibrocystic disease. SUVs correlate well with quantitative values, but future studies must determine whether treatment evaluation is also reliable with SUVs.

摘要

未标注

本研究的目的是比较L-[1-¹¹C]酪氨酸（TYR）和[¹⁸F]氟代-2-脱氧-D-葡萄糖（FDG）作为乳腺癌患者肿瘤示踪剂的价值，研究定量值与标准化摄取值（SUV）之间的相关性，并评估SUV在治疗评估中的价值。

方法

对11例有一个或多个乳腺恶性病变的患者和2例有一个或多个乳腺良性肿瘤的患者进行了TYR和FDG研究。静脉注射300MBq的TYR和230MBq的FDG。所有PET检查均使用西门子ECAT 951/31相机进行。对10个恶性肿瘤和3个良性病变进行了葡萄糖消耗和蛋白质合成率的定量分析。所有病变均使用基于体重、体表面积和瘦体重的SUV进行研究，且分别在有和没有校正血浆葡萄糖或酪氨酸水平的情况下进行。

结果

所有恶性肿瘤在FDG和TYR检查中均能显影，但FDG的视觉对比度更好。纤维囊性组织患者可见示踪剂摄取增加，这使肿瘤组织的视觉评估和轮廓勾画变得复杂。纤维囊性疾病中FDG的摄取比TYR更明显。两种示踪剂之间的肿瘤/非肿瘤比值没有差异。FDG在一个良性病变中显示出假阳性结果。尽管当SUV基于体表面积并校正血浆葡萄糖水平时，观察到葡萄糖消耗与SUV之间的最佳相关性（r = 0.85 - 0.87），但上述定义的SUV之间未发现重大差异。发现基于瘦体重的SUV与蛋白质合成率的相关性最佳（r = 0.83 - 0.94）。