Leonard B A, Lopez-Goni I, Baldwin C L
Department of Microbiology, Ohio State University, Columbus 43210, USA.
Vet Res. 1997;28(1):87-92.
Addition of 2,3-dihydroxybenzoic acid, a siderophore produced by Brucella abortus, to macrophage cultures prevented intracellular killing of brucellae during the first 12 h after infection and increased the number of intracellular brucellae recovered at 48 h after infection. The protective effect could be demonstrated with inflammatory macrophages, interferon-gamma-activated macrophages and with macrophages supplemented with iron, shown elsewhere to facilitate killing of B abortus.
向巨噬细胞培养物中添加流产布鲁氏菌产生的一种铁载体2,3 - 二羟基苯甲酸，可在感染后的最初12小时内防止细胞内布鲁氏菌被杀伤，并增加感染后48小时回收的细胞内布鲁氏菌数量。这种保护作用在炎性巨噬细胞、γ干扰素激活的巨噬细胞以及补充了铁的巨噬细胞中都能得到证实，其他研究表明补充铁有助于杀伤流产布鲁氏菌。
