Lonych L I, Kysel'ov Ie M
Mikrobiol Z. 1997 Jan-Feb;59(1):60-5.
Using two tuberculoproteins, phosphatide and polysaccharide antigens obtained from culture filtrate of pathogenic and vaccinal strains of Mycobacterium of human and bull types and standard monodispersed particles of latex modified by different chemical groups, the technology of creation of latex antigenic preparations for serologic express diagnosis of tuberculosis was elaborated. This method is based on the reaction of latex agglutination. Latex diagnostic preparation possesses sufficiently high serologic activity and specificity. The spectrum of microbacterial antigens allows one to characterize the status of immunity of patients with different forms of tuberculosis and to determine the degree of the process activity.
利用两种结核蛋白、从人型和牛型结核分枝杆菌致病菌株及疫苗菌株培养滤液中获得的磷脂和多糖抗原，以及经不同化学基团修饰的标准单分散乳胶颗粒，研发出了用于结核病血清快速诊断的乳胶抗原制剂技术。该方法基于乳胶凝集反应。乳胶诊断制剂具有足够高的血清学活性和特异性。微生物抗原谱可用于表征不同类型结核病患者的免疫状态，并确定病情活动程度。
