Teculescu D, Mur J M
INSERM Unité 420, Faculté de Médecine, Vandoeuvre-lés-Nancy, France.
Rev Epidemiol Sante Publique. 1997 Mar;45(1):64-77.
Sleep-disordered breathing includes snoring, upper airway resistance syndrome, sleep hypopneas and apneas, and is a borderline pathology between several disciplines (neurology, pneumology, cardiology, oto-rhino-laryngology, etc.). The common element is an abnormal increase in upper airway resistance during sleep. In mild cases, this increase accelerates airflow and induces vibrations of the pharyngeal structures (snoring); in severe cases the airway is occluded and airflow ceases (obstructive apnea). Sleep apnea syndrome (SAS) is present in 4% of males and 2% females in the general population. The risk factors are an age above 50, male sex, weight excess, presence of respiratory symptoms, tobacco smoking, alcohol consumption, use of hypnotic drugs... Snoring is much more frequent than sleep apnea, present in up to 50% of males aged 50 yr or more; most snorers do not have apneas ("simple" snorers). Apneas end with a micro-arousal; this sleep disruption explains the excess daytime sleepiness of patients with SAS. The daytime sleepiness is responsible for the increased rate of accidents (traffic, domestic, work...) in SAS patients. The second effect of apneas is desaturation, leading to heart rhythm abnormalities, coronary or cerebrovascular accidents, pulmonary vasoconstriction, systemic hypertension, etc. Screening for SAS is justified by its prevalence, by the potentially severe consequences and by the existence of an efficacious treatment: continuous positive airway pressure.
睡眠呼吸障碍包括打鼾、上气道阻力综合征、睡眠呼吸浅慢及呼吸暂停,是多个学科(神经科、呼吸科、心内科、耳鼻喉科等)之间的一种临界病理状态。其共同特征是睡眠期间上气道阻力异常增加。在轻度病例中,这种增加会加速气流并引发咽部结构振动(打鼾);在严重病例中,气道会阻塞且气流停止(阻塞性呼吸暂停)。普通人群中,4%的男性和2%的女性患有睡眠呼吸暂停综合征(SAS)。危险因素包括年龄超过50岁、男性、超重、存在呼吸道症状、吸烟、饮酒、使用催眠药物……打鼾比睡眠呼吸暂停更为常见,50岁及以上男性中高达50%存在打鼾;大多数打鼾者没有呼吸暂停(“单纯性”打鼾者)。呼吸暂停以微觉醒结束;这种睡眠中断解释了SAS患者日间过度嗜睡的原因。日间嗜睡导致SAS患者事故发生率增加(交通、家庭、工作等方面)。呼吸暂停的第二个影响是血氧饱和度下降,进而导致心律异常、冠状动脉或脑血管意外、肺血管收缩、系统性高血压等。鉴于SAS的患病率、潜在的严重后果以及有效治疗方法(持续气道正压通气)的存在,对其进行筛查是合理的。