氟康唑和两性霉素B对白色念珠菌的抗真菌药效学特性
Antifungal pharmacodynamic characteristics of fluconazole and amphotericin B tested against Candida albicans.
作者信息
Klepser M E, Wolfe E J, Jones R N, Nightingale C H, Pfaller M A
机构信息
College of Pharmacy, University of Iowa, Iowa City 52242-1112, USA.
出版信息
Antimicrob Agents Chemother. 1997 Jun;41(6):1392-5. doi: 10.1128/AAC.41.6.1392.
Abstract
Time-kill curves were determined for three isolates of Candida albicans tested against fluconazole and amphotericin B at multiples of the MIC. Fluconazole produced fungistatic activity, with concentration-related growth effects observed over a narrow range of concentrations. Amphotericin B exhibited fungicidal activity, with enhancement of activity over a broader range of concentrations.
摘要
针对白色念珠菌的三株分离株，测定了在 MIC 的倍数浓度下，其对氟康唑和两性霉素 B 的时间杀菌曲线。氟康唑产生抑菌活性，在较窄的浓度范围内观察到与浓度相关的生长效应。两性霉素 B 表现出杀菌活性，在更宽的浓度范围内活性增强。
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