Thullier F, Lalonde R, Cousin X, Lestienne F
Laboratoire de Biologie et Physiologie du Comportement, URA CNRS 1293, Université Henri Poincaré Nancy 1, Vandoeuvre-les-Nancy, France.
Brain Res Dev Brain Res. 1997 May 20;100(1):22-8. doi: 10.1016/s0165-3806(97)00010-2.
Lurcher mutant mice were compared to normal littermate controls for body weight, body righting, negative geotropism, sensorimotor coordination (rotating grid, wire suspension, rotorod), and visuomotor coordination requiring swimming toward a pole during postnatal (P) days 0-30. Lurcher mutants had a lower body weight on P20-P30 and were slower before performing the complete body righting response on P13-P30. Because of postural instability during the negative geotropism test, lurcher mutants turned quicker up the slope than normal mice. The mutants fell sooner from the rotating grid on P11-P14, from the horizontal wire on P15-P16, and from the rotorod on P14-P30. Lurcher mutants were also slower before swimming to the pole or climbing to the top of the pole and were inferior in pole climbing height on P22-P30. These results indicate test-selective and time-selective neurobehavioral deficits during ontogeny in a spontaneous cerebellar mutant.
在出生后（P）0至30天期间，将Lurcher突变小鼠与正常同窝对照小鼠进行比较，观察其体重、身体翻正、负向地性、感觉运动协调（旋转网格、钢丝悬吊、转棒）以及需要向杆游动的视觉运动协调情况。Lurcher突变小鼠在P20 - P30时体重较低，在P13 - P30进行完全身体翻正反应之前速度较慢。由于在负向地性测试中姿势不稳定，Lurcher突变小鼠比正常小鼠更快地向上坡翻转。突变小鼠在P11 - P14时更快地从旋转网格掉落，在P15 - P16时从水平钢丝掉落，在P14 - P30时从转棒掉落。Lurcher突变小鼠在游向杆或爬到杆顶之前也较慢，并且在P22 - P30时爬杆高度较低。这些结果表明，在一个自发性小脑突变体的个体发育过程中存在测试选择性和时间选择性的神经行为缺陷。
