Jović N, Cernak I, Cvetinović M
Military Medical Academy, Clinic for Maxillofacial Surgery, Belgrade.
Vojnosanit Pregl. 1996 May-Jun;53(3):177-85.
Idiopathic trigeminal neuralgia (ITN), resistant to the drug treatment was diagnosed in 20 patients using following parameters: clinical feature, usage of Bell-McGill questionnaire, as well as X-ray and neurophysiologic examinations. Peripheral neurectomy was performed in all of them as a palliative therapeutic procedure. In removed nerves of patients (n. infraorbitalis, n. alveolaris inferior), as well as in the same nerves of cadavers, the concentrations of prostaglandins (PGs) E2, F2 alpha and D2 were determined using commercial radioimmunoassay. Significant increase in PGE2 and PGF2 alpha concentration and simultaneous decrease in PGD2 concentration in the nerves of the patients with ITN was noticed. Results demonstrated that the increase in the concentration of hyperalgesic PGE2 and PGF2 alpha as well as the decrease in hypoalgesic PGD2 concentration had an important role in the onset of neuralgic pain in patients with ITN.
20例对药物治疗耐药的特发性三叉神经痛（ITN）患者通过以下参数进行诊断：临床特征、使用贝尔 - 麦吉尔问卷以及X线和神经生理学检查。对所有患者均实施了外周神经切除术作为姑息性治疗手段。采用商业放射免疫分析法测定患者切除神经（眶下神经、下牙槽神经）以及尸体相同神经中前列腺素（PGs）E2、F2α和D2的浓度。结果发现，ITN患者神经中PGE2和PGF2α浓度显著升高，同时PGD2浓度降低。结果表明，致痛性PGE2和PGF2α浓度升高以及镇痛性PGD2浓度降低在ITN患者神经痛发作中起重要作用。
