Takahata R, Matsumura H, Eguchi N, Kantha S S, Satoh S, Sakai T, Kondo N, Hayaishi O
Osaka Bioscience Institute, Japan.
Prostaglandins Leukot Essent Fatty Acids. 1996 Jan;54(1):77-81. doi: 10.1016/s0952-3278(96)90085-x.
Seasonal changes in the in vivo levels of the prostaglandins (PGs) PGD2, PGE2, and PGF2(alpha) were measured in the brain of the male Asian chipmunk, Tamias asiaticus (n = 111), which underwent hibernation during the period between November and March. The mean level of PGD2 ranged from 36.0 to 85.2 pg/g tissue from June to October and remained essentially unchanged (80.5 pg/g tissue) in December. However, the mean PGD2 level rose significantly to 128.6 pg/g tissue in February, and returned to 75.2 pg/g tissue in the following April, suggesting a correlation between PGD2 and hibernation phenomenon. While PGE2 level did not vary significantly throughout the year, PGF2(alpha), which appeared to be the most abundant among the three prostanoids, showed a marked circannual rhythm with a trough of 51.6 pg/g tissue in July, rising to 391.6 pg/g tissue in February and reaching the peak value of 492.7 pg/g tissue in April, the reproduction period.
在11月至3月期间经历冬眠的雄性亚洲花栗鼠（Tamias asiaticus，n = 111）的大脑中，测量了前列腺素（PGs）PGD2、PGE2和PGF2α的体内水平的季节性变化。PGD2的平均水平在6月至10月期间为36.0至85.2 pg/g组织，在12月基本保持不变（80.5 pg/g组织）。然而，PGD2的平均水平在2月显著上升至128.6 pg/g组织，并在次年4月恢复至75.2 pg/g组织，这表明PGD2与冬眠现象之间存在相关性。虽然PGE2水平在全年没有显著变化，但PGF2α似乎是三种前列腺素中含量最丰富的，呈现出明显的年周期节律，7月低谷为51.6 pg/g组织，2月升至391.6 pg/g组织，并在繁殖期4月达到峰值492.7 pg/g组织。
