Le Corre P A, Peskind E R, Chevanne F, Raskind M A, Le Verge R
Laboratoire de Pharmacie Galénique, Université de Rennes I, France.
Eur J Clin Pharmacol. 1997;52(2):135-8. doi: 10.1007/s002280050262.
The plasma and cerebrospinal fluid (CSF) disposition of yohimbine (YO) and 11-hydroxy-yohimbine (11-OH-YO), after oral administration of a single dose of YO (0.65 mg.kg-1) were studied in young and older healthy subjects and in patients with Alzheimer's disease (AD).
Plasma disposition of YO displayed large variability; no significant differences among subject groups were observed. In contrast, 11-OH-YO Cmax and AUC were significantly lower in the older normal subjects than in the young normal or AD subjects. A strong positive correlation between CSF and plasma YO concentrations was observed. A weak positive correlation between CSF and plasma concentrations of 11-OH-YO was also observed. CSF to plasma concentration ratios for yohimbine and 11-OH-YO were low (approximately 2%).
在年轻和年长的健康受试者以及阿尔茨海默病（AD）患者中，研究单次口服育亨宾（YO，0.65毫克·千克-1）后其血浆和脑脊液（CSF）中育亨宾（YO）及11-羟基育亨宾（11-OH-YO）的处置情况。
YO的血浆处置表现出很大的变异性；未观察到各受试者组之间有显著差异。相比之下，年长正常受试者中11-OH-YO的Cmax和AUC显著低于年轻正常受试者或AD受试者。观察到CSF和血浆中YO浓度之间存在强正相关。还观察到CSF和血浆中11-OH-YO浓度之间存在弱正相关。育亨宾和11-OH-YO的CSF与血浆浓度比很低（约2%）。
